Advances in Regenerative Therapy for Auricular Reconstruction in Congenital Microtia

Main Article Content

Paola Saskia Castañeda Anaya
Héctor Alan Mendoza Sánchez

Abstract

Advances in regenerative therapy have sparked significant interest in the field of auricular reconstruction for congenital microtia. Congenital microtia is a rare congenital deformity characterized by underdevelopment or absence of the external ear. Traditional surgical approaches using autologous grafts or artificial implants have limitations. Regenerative therapy offers innovative solutions by leveraging tissue engineering, biomaterials, and stem cells to create patient-specific and anatomically accurate external ears. This literature review explores the theoretical framework, surgical treatment, and potential complications of regenerative therapy for auricular reconstruction. Promising outcomes and future perspectives highlight the potential of regenerative therapy in providing more natural, functional, and personalized solutions for individuals with congenital microtia. Continued research and collaboration are crucial to advancing this field and improving the lives of those affected by microtia.

Article Details

How to Cite
Paola Saskia Castañeda Anaya, & Héctor Alan Mendoza Sánchez. (2023). Advances in Regenerative Therapy for Auricular Reconstruction in Congenital Microtia. International Journal of Medical Science and Clinical Research Studies, 3(8), 1548–1550. https://doi.org/10.47191/ijmscrs/v3-i8-16
Section
Articles

References

I. Ciorba, A., & Martini, A. (2006). Tissue engineering and cartilage regeneration for auricular reconstruction. International journal of pediatric otorhinolaryngology, 70(9), 1507-1515.

II. Chung, J. H., Kade, J., Jeiranikhameneh, A., Yue, Z., Mukherjee, P., & Wallace, G. G. (2018). A bioprinting printing approach to regenerate cartilage for microtia treatment. Bioprinting, 12, e00031.

III. Zhou, G., Jiang, H., Yin, Z., Liu, Y., Zhang, Q., Zhang, C., ... & Cao, Y. (2018). In vitro regeneration of patient-specific ear-shaped cartilage and its first clinical application for auricular reconstruction. EBioMedicine, 28, 287-302.

IV. Zhang, L., He, A., Yin, Z., Yu, Z., Luo, X., Liu, W., ... & Zhou, G. (2014). Regeneration of human-ear-shaped cartilage by co-culturing human microtia chondrocytes with BMSCs. Biomaterials, 35(18), 4878-4887.

V. Jovic, T. H., Gibson, J. A., Griffiths, R., Dobbs, T. D., Akbari, A., Wilson-Jones, N., ... & Whitaker, I. S. (2021). Microtia: a data linkage study of epidemiology and implications for service delivery. Frontiers in Pediatrics, 9, 630036.

VI. Otto, I. A., Melchels, F. P. W., Zhao, X., Randolph, M. A., Kon, M., Breugem, C. C., & Malda, J. (2015). Auricular reconstruction using biofabrication-based tissue engineering strategies. Biofabrication, 7(3), 032001.

Most read articles by the same author(s)